| In Development | Observational | Single Site | Kartik Iyer, Michaela Waak & Karen Barlow | Predicting clinical recovery in childhood stroke is highly challenging due to the complex nature of injury. Outcomes in these children remain unclear until months after...
Research Studies
Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)
| Enrolling | Clinical Trial | Multi-site | StrokeNet NIH | Sharon L. Ramey & Warren Lo | This is a Phase III clinical trial to compare the efficacy of two dosages of a new infant rehabilitation protocol - I-ACQUIRE - to usual and customary forms of infant...
Vascular effects of Infection in Pediatric Stroke (VIPS)
| Enrolling | Observational | Multi-site | NIH | Heather Fullerton | VIPS II is an international multi-center NIH funded study that proposes to enroll 200 pediatric stroke cases and 200 pediatric stroke-free cases. Biological specimens, imaging, parent interviews and...
PASTA (Paediatric Arteriopathy Steroid Aspirin: high dose steroids in children with stroke and unilateral focal arteriopathy) trial. EudraCT 2017-002247-15
|In Development |Clinical Trial |Multi-Site study | Maja Steinlin, Stéphane Chabrier & Manoëlle Kossorotoff | The main goal of PASTA is to determine if a short high dose course of Methylprednisolone/Prednisolone (three intravenous pulses followed by a 4-week oral...
Feasibility, Safety and Outcome of Endovascular Recanalization in Childhood Stroke: a worldwide multicenter prospective registry (Save ChildS Pro)
| Enrolling | Prospective Observational Registry |Multi-Site | Peter Sporns | Save ChildS Pro is a prospective registry including all pediatric patients with large vessel occlusion arterial ischemic stroke either treated with endovascular thrombectomy or best medical...
Seizures in Pediatric Stroke (SIPS)
| Closed | Observational | Multi-site | PERF | Christine Fox| SIPS II is an international multi-center PERF funded study that proposed to enroll 300 neonatal and pediatric stroke cases. Imaging, EEGs, medical chart abstraction and epilepsy longitudinal outcome data...
Examination of PTSD, Anxiety, Depression in parents and children with pediatric arterial ischemic stroke (AIS) and association with stroke outcome (PIPS)
| Enrolling | Observational | Multi-site | Boston Children’s Hospital | Laura Lehman| The PIPS study is a prospective multi-site IPSS sub-study that investigates the association between emotional outcomes (PTSD, anxiety, and depression) and AIS. The study uses...
Advanced Neuroimaging in Pediatric Stroke: Pathophysiology of Injury and Repair in Children with Focal Brain Ischemia
| Enrolling | Observational | Multi-site | Brain Canada | Noma Dlamini | The Brain Canada study is the first multi-center, international, advanced prospective neuroimaging study in childhood stroke. The study focuses on using novel neuroimaging techniques to...
Safety and Efficacy of Systemic Anticoagulation Therapy for Treatment of Cerebral Sinus Venous
| Enrolling |Observational |Single Site |Marcela Torres| Keyword(s): Sinus venous thrombosis, anticoagulation, thrombolytic therapy Contact information: Fernando Acosta, Jo Tilley, . Marcela Torres,...
Risk Factors Associated With Stroke in Pediatric Patients Undergoing Fontan
| Enrolling |Observational |Single Site | Jay Duncan | Keyword(s): Arterial ischemic stroke, single ventricle, Fontan, congenital heart disease Contact information: Fernando Acosta, Jo Tilley, . Marcela...
Rehabilitation Early for Congenital Hemiplegia
|Enrolling |Clinical Trial | Multi-Site |Professor Roslyn Boyd | The REACH multisite assessor masked randomized Comparison trial directly compares an equal dose of infant modified Constraint Induced Movement Therapy (Baby CIMT) with infant modified Bimanual upper limb...
AVCnn (Accident vasculaire cérébral du nouveau-né; Stroke of the newborn) & ancillary AVCnnsignal (brain structural and functional imaging) and AVCnn7ans (global assessment at 7 years). NCT02511249; EudraCT 2010-A00329-30; EndraCT 2010-A00976-33
| Enrolling | Observational |Single Site | Stéphane Chabrier & Sylvie Nguyen The Tich| The AVCnn Study provides us the opportunity to monitor a cohort of children having suffered an NAIS, and their family. Briefly, 100 term newborns (64 males) with an arterial...